Days before his release from prison, Shadow's wife, Laura, dies in a mysterious car crash. Numbly, he makes his way back home. On the plane, he encounters the enigmatic Mr Wednesday, who claims to be a refugee from a distant war, a former god and the king of America.
Together they embark on a profoundly strange journey across the heart of the USA, whilst all around them a storm of preternatural and epic proportions threatens to break.